Published Research
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2013 Published Research
Biosynthesis of highly enriched 13C-lycopene for human metabolic studies using repeated batch tomato cell culturing with13C-glucose.Food Chemistry. August 2013. Nancy Engelmann Moran, Randy B. Rogers, Chi-Hua Lue, Lauren E. Conlon, Mary Ann Lila, Steven K. Clinton, John W. Erdman Jr. Division of Medical Oncology, Department of Internal Medicine, and the Comprehensive Cancer Center, The Ohio State University; Department of Natural Resources and Environmental Sciences, The University of Illinois, Urbana; The Division of Nutritional Sciences, The University of Illinois, Urbana; Plants for Human Health Institute, North Carolina State University, NC Research Campus; Department of Food Science and Human Nutrition, University of Illinois, Urbana.
Efficient Quantification of the Health-Relevant Anthocyanin and Phenolic Acid Profiles in Commercial Cultivars and Breeding Selections of Blueberries ( Vaccinium spp.). Journal of Agricultural Food Chemistry (Epub). May 13, 2013. Yousef GG, Brown AF, Funakoshi Y, Mbeunkui F, Grace MH, Ballington JR, Loraine A, Lila MA. Department of Horticultural Science and Department of Food Bioprocessing and Nutrition Sciences, Plants for Human Health Institute and UNC Charlotte Genomics and Bioinformatics, North Carolina Research Campus.
Steroidal glycosides from the bulbs of Easter lily (Lilium longiflorum Thunb.) promote dermal fibroblast migration in vitro. Journal of Ethnopharmacology. May 2, 2013 (Epub). Esposito D, Munafo JP, Lucibello T, Baldeon M, Komarnytsky S, Gianfagna TJ. Department of Plant Biology and Pathology, Rutgers-The State University of New Jersey; North Carolina State University Plants for Human Health Institute, North Carolina Research Campus.
Bioactive Polyphenols from Muscadine Grape and Blackcurrant Stably Concentrated onto Protein-rich Matrices for Topical Applications. International Journal of Cosmetic Science. April 2013. Plundrich N, Grace MH, Raskin I, Lila MA. Plants for Human Health Institute, Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, North Carolina Research Campus, 600 Laureate Way, Kannapolis, NC, 28081, USA.
Effects of a flavonoid-rich juice on inflammation, oxidative stress, and immunity in elite swimmers: a metabolomics-based approach. International Journal of Sport Nutrition and Exercise Metabolism. April 2013. Knab AM, Nieman DC, Gillitt ND, Shanely RA, Cialdella-Kam L, Henson DA, Sha W. Human Performance Laboratory, Appalachian State University.
Validity of COSMED's Quark CPET Mixing Chamber System in Evaluating Energy Metabolism During Aerobic Exercise in Healthy Male Adults. Research in Sports Medicine. April 2013. Nieman DC, Austin MD, Dew D, Utter AC. Department of Health, Leisure, and Exercise Science, Human Performance Lab, Appalachian State University.
Irisin levels correlate with energy expenditure in a subgroup of humans with energy expenditure greater than predicted by fat free mass. Metabolism. April 2013. Andrew G. Swick, Stephen Orena, Annalouise O’Connor. UNC Nutrition Research Institute, University of North Carolina Chapel Hill, North Carolina Research Campus.
Rapid emergence of a ceftazidime-resistant Burkholderia multivorans strain in a Cystic Fibrosis patient. Journal of Cystic Fibrosis. March 2013. Joshua R. Stokell, Raad Z. Gharaibehb, Todd R. Steck. Department of Biology, University of North Carolina at Charlotte, Bioinformatics Services Division, Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Kannapolis.
Antiplasmodial activity of cucurbitacin glycosides from Datisca glomerata (C. Presl) Baill. Phytochemistry. March 2013. Rocky Graziosea, Mary H. Grace, Thirumurugan Rathinasabapathyd, Patricio Rojas-Silva, Carmen Dekock, Alexander Pouleva, Mary Ann Lila, Peter Smith, Ilya Raskina. Department of Plant Biology and Pathology, SEBS, Rutgers, The State University of New Jersey; Plants for Human Health Institute, North Carolina State University, North Carolina Research Campus; Division of Pharmacology, University of Cape Town Medical School, South Africa; Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia.
Reduction of major peanut allergens Ara h 1 and Ara h 2, in roasted peanuts by ultrasound assisted enzymatic treatment. Food Chemistry. March 2013. Hao Lia, Jianmei Yub, Mohamed Ahmednaa, Ipek Goktepeb. Center for Excellence in Post-Harvest Technologies, North Carolina Research Campus; Department of Family and Consumer Sciences, North Carolina A&T State University; College of Biological Science and Technology, Fuzhou University, China.
SNP discovery and chromosome anchoring provide the first physically-anchored hexaploid oat map and reveal synteny with model species. PloS One. March 22, 2013. Oliver RE, Tinker NA, Lazo GR, Chao S, Jellen EN, Carson ML, Rines HW, Obert DE, Lutz JD, Shackelford I, Korol AB, Wight CP, Gardner KM, Hattori J, Beattie AD, Bjørnstad A, Bonman JM, Jannink JL, Sorrells ME, Brown-Guedira GL, Mitchell Fetch JW, Harrison SA, Howarth CJ, Ibrahim A, Kolb FL, McMullen MS, Murphy JP, Ohm HW, Rossnagel BG, Yan W, Miclaus KJ, Hiller J, Maughan PJ, Redman Hulse RR, Anderson JM, Islamovic E, Jackson EW. General Mills Crop Biosciences, Kannapolis, North Carolina, United States of America.
Choline's role in maintaining liver function: new evidence for epigenetic mechanisms. Current Opinion in Clinical Nutrition and Metabolomic Care. March 13, 2013. Mehedint, MG, Zeisel SH. Nutrition Research Institute at the NC Research Campus, Kannapolis, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
New insight into the structure of RNA in red clover necrotic mosaic virus and the role of divalent cations revealed by small-angle neutron scattering. Archives of Virology. March 13, 2013. Martin SL, He L, Meilleur F, Guenther RH, Sit TL, Lommel SA (Plants for Human Health Institute and DHMRI, NC Research Campus) and D, Heller WT. Department of Plant Pathology, North Carolina State University, Raleigh, NC, 27695, USA.
Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors. Carcinogenesis. March 4 2013. Chiou YS, Sang S (NC A&T Center for Excellence in Post Harvest Technologies at the NC Research Campus), Cheng KH, Ho CT, Wang YJ, Pan MH. Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung 811, Taiwan.
Blueberry polyphenol-enriched soybean flour reduces hyperglycemia, body weight gain and serum cholesterol in mice. Pharmacological Research. February 2013. Roopchand DE, Kuhn P, Rojo LE, Lila MA, Raskin I. Rutgers, The State University of New Jersey, School of Environmental and Biological Sciences; Plants for Human Health Institute, North Carolina State University, 600 Laureate Way, Kannapolis, NC 28081.
Effects of pregnane glycosides on food intake depend on stimulation of the melanocortin pathway and BDNF in an animal model. Journal of Agricultural and Food Chemistry. February 27, 2013. Komarnytsky S, Esposito D, Rathinasabapathy T, Poulev A, Raskin I. NC State University Plants for Human Health Institute, NC Research Campus.
Pregestational nutrition and the epigenetic landscape in next generations: still an almost virgin land to be explored. Epigenomics. February 2013. Niculescu MD. Department of Nutrition & UNC Nutrition Research Institute, University of North Carolina at Chapel Hill. NC Research Campus.
Melamine-induced renal toxicity is mediated by the gut microbiota. Science Translational Medicine. February 13, 2013. Zheng X,Zhao A, Xie G, Chi Y, Zhao L, Li H, Wang C, Bao Y, Luther M, Su M, Nicholson JK, Jia W. Shanghai Key Laboratory of Diabestes Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China; School of Pharmacy Shanghai Tong University, Shanghai, China; Center for Translational Biomedical Research, University of North Carolina at Greensboro, NC Research Campus, Kannapolis, NC USA; David H. Murdock Research Institute, NC Research Campus, Kannapolis, NC USA; Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London, UK.
Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis. FASEB Journal. February 1, 2013. Corbin KD, Abdelmalek MF, Spencer MD, da Costa KA, Galanko JA, Sha W, Suzuki A, Guy CD, Cardona DM, Torquati A, Diehl AM, Zeisel SH. University of North Carolina at Chapel Hill Nutrition Research Institute,
Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness.Metabolism: Clinical and Experimental. January 31, 2013. Batch BC, Shah SH, Newgard CB, Turer CB, Haynes C, Bain JR, Muehlbauer M, Patel MJ, Stevens RD, Appel LJ, Newby LK, Svetkey LP. Division of Endocrinology, Metabolism, and Nutrition, Duke University Medical Center, Durham, NC 27710, USA; Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, NC 27710, USA. The study was conducted as part of the Measurement to Understand the Reclassification of Disease of Cabarrus/Kannapolis (MURDOCK) project.
Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: chemical synthesis and biological evaluation. PloSOne, January 30, 2013. Zhu Y, Warin RF, Soroka DN, Chen H, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University.
Structure Elucidation and Chemical Profile of Sphingolipids in Wheat Bran and Their Cytotoxic Effects against Human Colon Cancer Cells. Journal of Agricultural and Food Chemistry. January 30, 2013. Zhu Y, Soroka DN, Sang S.Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus.
Serum derived exosomes evaluated early in second trimester provide predictive biomarkers of risk for preterm birth before week 34. American Journal of Obstetrics and Gynecology. January 2013. Alan Ezrin, Brian Brohman, Sarah Baxter, Keith Moore, Mike Luther. NX PharmaGen Inc., Maternal Fetal Medicine Program, Louisville, KY, David H. Murdock Research Institute- Dept. of Immunobiology and Dept. of Analytical Science.
The heterodimerization of platelet-derived chemokines. Biochimica et Biophysica Acta (BBA)- Proteins and Proteomics. January 2013. James Carlson, Sarah A. Baxter, Didier Dréau, Irina V. Nesmelova. Analytical Sciences Laboratory, David H. Murdock Research Institute and the Department of Biology, Department of Physics and Optical Science and the Center for Biomedical Engineering and Science, University of North Carolina at Charlotte.
Continuous infusion of 20-hydroxyecdysone increased mass of triceps brachii in C57BL/6 mice.Phytotherapy Research. January 27, 2013. Cheng DM, Kutzler LW, Boler DD, Drnevich J, Killefer J, Lila MA (NC State Plants for Human Health Institute). Department of Natural Resources and Environmental Sciences, University of Illinois, Urbana, IL 61801.
Polymeric Systems Incorporating Plant Viral Nanoparticles for Tailored Release of Therapeutics. Advanced Healthcare Materials. January 20, 2013. Honarbakhsh S, Guenther RH, Willoughby JA, Lommel SA (Plants for Human Health Institute and DHMRI, NC Research Campus), Pourdeyhimi B. The Nonwovens Institute, North Carolina State University, 2401 Research Drive, Raleigh, North Carolina, 27695 USA.
A metabolomics-based strategy for the quality control of traditional chinese medicine: shengmai injection as a case study. Evidence-based Complementary and Alternative Medicine. January 20, 2013. Li X, Chen H, Jia W, Xie G. College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian China; Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis.
Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metabolism. January 8, 2013. Parks BW, Nam E, Org E, Kostem E, Norheim F, Hui ST, Pan C, Civelek M, Rau CD, Bennett BJ (UNC Chapel Hill Nutrition Research Institute), Mehrabian M, Ursell LK, He A, Castellani LW, Zinker B, Kirby M, Drake TA, Drevon CA, Knight R, Gargalovic P, Kirchgessner T, Eskin E, Lusis AJ. Department of Medicine/Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA.
Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metabolism. January 8, 2013. Bennett BJ (UNC Chapel Hill Nutrition Research Institute), Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen SL, Lusis AJ. Department of Medicine, University of California, Los Angeles.
Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol. Molecular Nutrition and Food Research. January 16, 2013. Chen H, Soroka DN, Hu Y, Chen X, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University.
Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human. Molecular Nutrition and Food Research. January 16, 2013. Chen H, Soroka D, Zhu Y, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University.
Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis. FAESB Journal. January 2013. Corbin KD, Abdelmalek MF, Spencer MD, da Costa KA, Galanko JA, Sha W, Suzuki A, Guy CD, Cardona DM, Torquati A, Diehl AM, Zeisel SH. University of North Carolina at Chapel Hill Nutrition Research Institute.